Shana E. McCormack, MD
- Assistant Professor of Pediatrics
Children’s Hospital of Philadelphia
34th and Civic Center Boulevard
Division of Endocrinology and Diabetes
11NW, Suite 30
- Phone: 2155903174
Description of Research Expertise
I study the neuroendocrine systems that regulate energy balance in humans. Our translational research program has two main areas of focus. First, we study individuals with metabolic disorders with characterized by risk for diabetes mellitus, including primary mitochondrial diseases, Friedreich's ataxia, and lipodystrophy. Second, we focus on brain disorders associated with excess weight gain, including brain-tumor related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
We perform detailed assessments of mitochondrial bioenergetics and metabolism in humans with these conditions using, for example, non-invasive imaging techniques, stable isotopes, and integrated metabolomics and proteomics. We complement these in vivo studies with in vitro experiments to more fully explore the tissue-specific causes and consequences of abnormal energy balance in model systems such as patient-derived cell lines.
Insights from these rare conditions can then be leveraged to better understand and treat common disorders of energy balance like obesity and diabetes mellitus.
Selected PublicationsRoy SM, Kelley J, Hanley P, McCormack SE, Grant SFA: Genetics of pediatric obesity.Childhood obesity: causes, consequences, and intervention approaches. Goran M (eds.). CRC press, Oct 2016.
Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF: Rare EN1 variants and pediatric bone mass. J Bone Miner Res 31(8): 1513-7, Aug 2016.
Sheldon CA, Lin GL, Szperka CL, McCormack SE, Liu GT.: Pediatric pseudotumor cerebri syndrome. Practical management of pediatric ocular disorders and strabismus Traboulsi EI, Utz V, Ariss M (eds.). Springer Science, Aug 2016.
Mitchell JA, Chesi A, Elci O, McCormack SE, Roy S, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS: Physical activity benefits the skeleton of children genetically predisposed to lower bone density in adulthood. J Bone Miner Res 31(8): 1504-12, Aug 2016.
McCormack SE, Chesi A, Mitchell JA, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer KK, Kelly A, Grant SFA, Zemel BS: Relative skeletal maturation and population ancestry in non-obese children and adolescents. J Bone Miner Res Jul 2016.
Kwon YJ, Allen J, Liu GT, McCormack SE: Presumed pseudotumor cerebri syndrome after withdrawal of inhaled glucocorticoids. Pediatrics 137(6), Jun 2016.
McCormack SE, Xiao R, Kilbaugh T, Karsson M, Falk MJ, Damrauer SM: Hospitalizations related to mitochondrial disease in the U.S. United Mitochondrial Disease Foundation Annual Mitochondrial Medicine Symposium, Seattle WA, Platform Presentation. Jun 2016.
Roy S, Spivack J, Faith M, Chesi A, Mitchell J, Kelly A, Grant SFA, McCormack SE, Zemel B: Infant BMI or weight-for-length and obesity risk in early childhood. Pediatrics 137(5), May 2016.
DeBrosse C, Nanga RPR, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Zolkipli-Cunningham Z, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE : Measurement of OXPHOS capacity in mitochondrial diseases with a novel imaging method: Creatine Chemical Exchange Saturation Transfer (CrCEST). NHLBI/NIDDK Mitochondrial Biology Symposium, Bethesda MD, Platform Presentation. May 2016.
Isaacs CJ, Brigatti KW, Kucheruk O, Ratcliffe S, Sciascia T, McCormack SE, Willi SM, Lynch DR: Effects of genetic severity on glucose homeostasis in Friedreich Ataxia. Muscle & Nerve Apr 2016.