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Post Doctoral Fellow
Address:
Children’s Hospital of Philadelphia Research Institute
Colket Translational Research Building
3501 Civic Center Boulevard, Room 6100
Philadelphia, PA 
19104
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 267-425-3063

Research Statement

Dr. Tal Yardeni graduated from the laboratory of Dr. William Gahl, National Human Genome Research Institute/NIH, in collaboration with Tel-Aviv University, Israel.  The topic of her Ph.D. thesis was, “Sialic acid in health and disease: molecular, cellular, pathological and therapeutic aspects”. Her research focused on exploring treatment options for Hereditary Inclusion Body Myopathy (HIBM). After completing her Ph.D. she moved to the Weizmann Institute of Science in Israel as a post-doctoral fellow with Dr. Eran Hornstein. In the Hornstein lab, she studied the role of microRNAs in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS).  In March 2015 she joined the lab of Dr. Douglas C. Wallace in the Center for Mitochondrial and Epigenomic Medicine at the Children’s Hospital of Philadelphia. Her main goals are: A. to explore the role of mitochondrial function on the regulation of the microbiome community. B. to study the role of mitochondrial function on the regulation of the immune system and cancer. C. to investigate the role of mitochondrial dysfunction in autism and additional neurodegeneration disorders.

 

Selected Publications

  1. Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, Wu GD, Murdock DG, Wallace DC. Host mitochondria influence gut microbiome diversity: A role for ROS. Sci Signal. 2019 Jul 2;12(588). pii: eaaw3159. doi: 10.1126/scisignal.aaw3159.
  2. Malicdan MCV, Vilboux T, Ben-Zeev B, Guo J, Eliyahu A, Pode-Shakked B, Dori A, Kakani S, Chandrasekharappa SC, Ferreira C, Shelestovich N, Marek-Yagel D, Pri-Chen H, Blatt I, Niederhuber JE, He L, Toro C, Taylor RW, Deeken J, Yardeni T, Wallace DC, Gahl WA, Anikster Y. A novel inborn error of the Coenzyme Q10 biosynthesis pathway: Cerebellar ataxia and static encephalomyopathy due to COQ5 C-Methyltransferase deficiency. Hum Mutat. 2017  doi: 10.1002/humu.23345
  3. Barel O, Christine V Malicdan M, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, Ganelin E, Barshack I, Polak-Charcon S, Nass D, Marek-Yagel D, Amariglio N, Shalva N, Vilboux T, Ferreira C, Pode-Shakked B, Heimer G, Hoffmann C, Yardeni T, Nissenkorn A, Avivi C, Eyal E, Kol N, Glick Saar E, Wallace DC, Gahl WA, Rechavi G, Schrader M, Eckmann DM, Anikster Y. Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy. 2017 1;140(3):568-581
  4. Yardeni T, Fine R, Joshi Y, Gradus-Pery T, Kozer N, Reichenstein I, Yanowski E, Katz S, Weiss H, Eisenberg M, Shalit T, Plotnikov A, Barr H.M, Perlson E and Hornstein E. High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria. Sci Rep. 2018 Jan 8;8(1):59. doi: 10.1038/s41598-017-17878-x.
  5. Yardeni T and Hornstein E. Protocol for high content screening for the impact of overexpressed microRNAs on primary motor neurons. Neuro methods, (Book Chapter) 2015,
  6. Yardeni T, Ciccone C, Anikster Y, Kurochkina N, Gahl WA, Huizing M. Murine isoforms of UDP-GlcNAc 2-epimerase/ManNAc kinase: Secondary structures, expression profiles, and response to ManNAc therapy. Glycoconjugate Journal. 2012.
  7. Huizing M, Yardeni T, Fuentes F, Malicdan MCV, Leoyklang P, Volkov A, Dekel B, Brede E, Blake J, Powell A, Chatrathi H, Anikster Y, Nuria Carrillo N, Gahl WA, Kopp JB. Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases. Kidney International Reports 2019, in press.
  8. Niethamer TK, Yardeni T, Leoyklang P, Ciccone C, Astiz-Martinez A, Jacobs K, Dorward HM, Zerfas PM, Gahl WA, Huizing M. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Molecular Genetics and Metabolism, 2012 107(4):748-55.
  9. Yardeni T, Ciccone C, Patzel K, Anikster Y, Kurochkina N, Gahl WA, Huizing M. Identification, Tissue Distribution and Molecular Modeling of Novel Human Isoforms of the Key Enzyme in Sialic Acid Synthesis, UDP-GlcNAc 2-epimerase/ManNAc Kinase. Biochemistry, 2011 18;50(41):8914-25. [Epub ahead of print].
  10. Kakani S,* Yardeni T,* Poling S, Ciccone C, Vincent L, Dorward H, Patzel K, Klootwijk R, Manoli I, Darvish D, Hoogstraten-Miller S, Zerfas P, Tian E, Ten Hagen K, Kopp JB, Gahl WA, Huizing M. Characterization of the glomerulopathy in the Gne M712T mouse model which is partially rescued by supplementation with N-acetylmannosamine. The American Journal of Pathology, [Epub ahead of print]. [*co-first author]
  11. Huizing M, Yardeni T, Horstkorte R, Hinderlich S. UDP-GlcNAc 2-epimerase/ManNAc kinase, a master regulator of sialic acid synthesis. Top Curr Chem, ( Book Chapter), 2013
  12. Yardeni T, Eckhaus M, Huizing M, Hoogstraten-Miller S. Retro-Orbital Injections in Mice. Laboratory Animals 2011; 40:155-60.

 

Full list of published articles is available via the following URL: 

http://www.ncbi.nlm.nih.gov/pubmed/?term=yardeni+t

 

Additional information